Urosource: Today's Key Article

Characterisation of PCa lesions in heterozygous Men1 mutant mice

Edited by: JV

Thursday, 29 July 2010- Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology. Intriguingly, rare lesions in hormone-dependent tissues, such as prostate and mammary...

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Second to fourth digit ratio: a predictor of PSA level and PCa

Thursday, 29 July 2010- A group of Korean researchers conducted a study to investigate the relationships between the 2nd to 4th digit ratio (digit ratio) and prostate volume, prostate-specific antigen (PSA) level, and the presence of prostate cancer. They published their findings in an online...

Edited by: JV

Short rare hTERT-VNTR 2-2nd alleles linked with PCa susceptibility

Wednesday, 28 July 2010- The hTERT (human telomerase reverse transcriptase) gene contains five variable number tandem repeats (VNTR) and previous studies have described polymorphisms for hTERT-VNTR2-2nd.

Se-Lyun Yoon and colleagues investigated how allelic variation in hTERT-VNTR2-2nd may affect...

Edited by: JV

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Clinical efficacy of alpha1-Adrenargic Receptor Antagonist in BPH patients

Wednesday, 28 July 2010- K. Kadekawa and colleagues assessed the clinical efficacy and safety of 75 mg/day of naftopidil, an alpha1-adrenargic receptor antagonist in patients with benign prostatic hyperplasia (BPH). They published their findings in the online edition of the journal LUTS:...

Outcome of patients with localised PCa treated by radiotherapy

Tuesday, 27 July 2010- N. Suzuki and colleagues conducted a study on the outcome of patients with localised prostate cancer who underwent radiotherapy after confirming the absence of lymph node invasion. They published their findings in the Japanese Journal of Clinical Oncology.

"Management...

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Stone size is the only predictor of ESWL success in children

Wednesday, 28 July 2010- S. McAdams and colleagues conducted a study to determine whether age, gender, body mass index, number of stones, stone location or total stone diameter could independently predict stone-free rates after extracorporeal shock wave lithotripsy in children.

They published...

African Americans face higher risk of kidney failure caused by hypertension

Tuesday, 27 July 2010- Regardless of demographics, African American patients with hypertensive nephrosclerosis have a higher rate of developing end stage renal disease (ESRD) than dying prematurely, according to a study appearing in an upcoming issue of the Journal of the American Society of...

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New research model of prostate cancer growth shows role of sex hormones

Monday, 5 July 2010- Progress toward understanding the role of sex hormones in the growth of prostate cancer has been hindered by the lack of a suitable laboratory research model. Now US researchers say they have developed the first model of hormone-induced human prostate cancer initiation and...

Gout drug may decrease LVH in CKD patients

Thursday, 1 July 2010- Allopurinol, a drug long used to treat gout, can cause regression of left ventricular hypertrophy (LVH) and endothelial dysfunction in CKD patients, a study found.

The study is the first to show that allopurinol treatment is associated with these effects in CKD patients....

More upcoming

7th ESOU Meeting in Vienna to tackle emerging treatment options

Friday, 8 January 2010- Emerging treatment options that impact on the diagnosis of uro-genital cancers will be examined at the annual meeting of the EAU Section of Oncological Urology (ESOU) to be held in Vienna, Austria from January 15 to 17, 2010.

Prof. Bob Djavan, chairman of the 7th ESOU...

2nd EMUC to reach new heights of international cooperation

Thursday, 26 November 2009- Experts agree that the urological cancer patient will benefit greatly if the delivered treatment is a result of a combined effort. Collaboration of experts from various fields is, therefore, necessary to take cancer-related research and medical practice to the next...

What is your recommended treatment modality for a patient suffering from BPH at an early stage with a high risk of progression?

Second to fourth digit ratio: a predictor of PSA level and PCa

Short rare hTERT-VNTR 2-2nd alleles linked with PCa susceptibility