expert reviews
Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment
Review of: C.A., Siegel M.A., Elting L.S. Lancet Oncol 2006;7(6): 508–514.Although bisphosphonates have been used clinically for more than 30 years, complete knowledge of their pharmacokinetics and pharmacodynamics has not yet...
Surveillance for recurrent bladder cancer using a point-of-care proteomic assay
Review of: Grossman HB, Soloway M, Messing E, Katz G, Stein B, Kassabian V, Shen Y. JAMA. 2006 Jan 18;295(3):299-305 This study uses an identical design to a study published by the same group in 2005 on the detection of bladder...
Cancer immunotherapy: moving beyond current vaccines
The future looks bright if the following criteria can be met: (1) in vivo generation of sufficient numbers of immune cells to recognize tumor antigens (2) successful trafficking of these cells to infiltrate the tumor stroma, and...
Olfactory detection of human bladder cancer by dogs: proof of principle
Review of: Willis CM, Church SM, Guest CM, Cook WA, McCarthy N, Bransbury AJ, Church MRT and Church JCT. British Medical Journal 329, 712, September 2004At first sight this study seems simply amusing. However, although certainly...
Open mesh versus laparoscopic mesh repair of inguinal hernia
Review of: Neumayer L, Giobbie-Hurder A, Jonasson O, Fitzgibbons R Jr et al (Veterans Affairs Cooperative Study 456). N Engl J Med, 350 (18), 1819, April 2004 and A comparison of laparoscopically assisted and open colectomy for...
Adjuvant cisplatin plus methotrexate versus methotrexate, vinblastine, epirubicine and cisplatin in locally advanced bladder cancer: results of a randomized, multicenter phase III trial (AUO-AB 05/95).
Review of: J. Lehmann, M. Retz, C.Wiemers, J. Beck, J. Th¸roff et al. J Clin Oncol, 23, 22, 4963-4972, 2005.
This paper reports the results of a large multicenter trial conducted by the German Urological Oncology Group...
Detection of Bladder Cancer Using a Pointof- Care Proteomic Assay.
Review of: H.B. Grossman, E. Messing, M. Soloway, K. Tomera, G. Katz, Y. Berger,Y. Shen. JAMA 293, 810-816, 2005.In this prospective study the urine-based NMP22 point of care dip-stick test was evaluated. The study design was...
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and CancerA Randomized Controlled Trial
The major finding of the HOPE and HOPETOO trials, is the lack of benefit for vitamin E in preventing cancer or major cardiovascular events after a prolonged period of treatment and observation
Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study
Review of: Margaret R.Karagas, S.Park, A.Warren, J.Hamilton, H.H.Nelson, L.A.Mott, K.T.Kelsey. Cancer Letters 219, 63-69, 2005
Cigarette smoking is a, if not the, leading cause of bladder cancer since tobacco smoke contains...



