key articles
High expression of polo-like kinase 1 linked with bladder cancer recurrence and metastasis
Friday, 30 December 2011- Polo-like kinase 1 (Plk1) has been widely pursued as an oncology target because it is overexpressed in several human tumor types. To investigate whether Plk1 plays a general role in...
Edited by: JV
Randomised phase 2-3 trial: assessing gemcitabine/carboplatin and M-CAVI in advanced urothelial cancer patients
Thursday, 15 December 2011- M. De Santis and colleagues conducted the first randomised phase II/III trial comparing two carboplatin-based chemotherapy regimens in patients with urothelial cancer who are ineligible (“unfit”) for...
Edited by: JV
Upper urinary tract recurrence after radical cystectomy for BCa: incidence and risk factors
Monday, 5 December 2011- A group of Japanese researchers conducted a study to examine the incidence of and the risk factors for upper urinary tract recurrence in patients undergoing a radical cystectomy for bladder cancer, and to...
Edited by: JV
Salvage surgery after chemo: does it have clinical impact on survival of metastatic urothelial carcinoma patients?
Wednesday, 23 November 2011- The clinical impact of salvage surgery after chemotherapy on cancer survival of patients with metastatic urothelial carcinoma is controversial.
K. Bekku and colleagues conducted a study to verify...
Edited by: JV
Value of bladder mapping and prostatic urethra biopsies in detecting carcinoma in situ
Thursday, 10 November 2011- It is well known that CIS is a major risk factor for muscle-invasive bladder cancer and that this entity can be difficult to diagnose. Taking cold-cup mapping biopsies from different areas of the...
Edited by: JV
Radical cystectomy in elderly patients
Wednesday, 9 November 2011- V. Novotny and colleagues conducted a study to analyse the impact of comorbidity on the perioperative complication rate after radical cystectomy in patients over 70 year of age. They published their...
Edited by: JV
Predicting high-grade bladder cancer risk using noninvasive data
Thursday, 3 November 2011- N. Shapura and colleagues conducted a study to examine the hypothesis that the risk of high-grade bladder cancer can be predicted using noninvasively obtained data. They published their findings in the...
Edited by: JV
Adeno-associated virus-mediated HSV-TK/GCV suicide system: a strategy for treating bladder cancer
Wednesday, 26 October 2011- Novel treatment strategies such as gene therapy are warranted in view of the failure of current treatment approaches to cure a high percentage of patients with advanced bladder cancers. The emergence...
Edited by: JV
Smoking status: a risk factor for recurrence after transurethral resection of NMIBC
Tuesday, 11 October 2011- Cigarette smoking is the most well-established risk factor for developing bladder cancer. R. J.M. Lammers and colleagues conducted a study to investigate the role of smoking status on the clinical...
Edited by: JV
Trial of celecoxib to prevent recurrence of nonmuscle-invasive bladder cancer
Friday, 7 October 2011- Significant morbidity and expense result from frequent recurrences of nonmuscle-invasive bladder cancer (NMIBC) after standard treatment, and carcinoma in situ (Tis) is a poor prognostic factor....
Edited by: JV
