Androgen deprivation therapy for PCa: risk of skeletal fractures
Tuesday, 11 November 2008 - Androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) is considered the standard therapy over the last half of the previous century. Its use is associated with several adverse effects, and one of the most important long-term side effects is the loss of bone mineral density...
Edited by: JV
Sensitivity of tumour-associated Trypsin Inhibitor (TATI) in detecting urothelial cell carcinoma
Monday, 10 November 2008- Tumour-associated trypsin inhibitor is the 6-kDa-polypeptide marker which can be usually detected in elevated quantities in the blood, urine, or body tissues of patients with certain types of cancer. Sensitivity of TATI in the urothelial cell carcinoma diagnosis is reported between 20% to...
Edited by: JV
How to identify new classes of renal cell cancer
Friday, 7 November 2008 - Transcriptional profiling of small non-coding RNA gene products called miRNAs has emerged as a powerful approach to identify new cancer classes and predict clinical outcome. To evaluate the role of specific miRNAs for the development of RCC we analysed miRNA expression profiles.
miRNA...
Edited by: FGR
Extracorporeal shockwave lithotripsy in children
Friday, 7 November 2008 - Extracorporeal shockwave lithotripsy (ESWL) represents a well-established and effective treatment of urinary stones in adult patients. Ignorance about indication varieties and side effect on ESWL in paediatric patients still causes unnecessary stone surgery.
Lead author Dr. Rucsandra Manu...
Edited by: JV
Neurotoxin influences the chemical coding of DRG: an experimental study on porcine models
Thursday, 6 November 2008 - At present, resiniferatoxin (RTX) is used in experimental therapy as a drug, which can abolish the activity of afferent neurons involved in abnormal neural circuits causing micturition disorders during various neurogenic diseases. RTX and tetradotoxin (TTX) have not only different...
Edited by: JV
Claudin-pattern in prostate cancer: a new diagnostic marker?
Wednesday, 5 November 2008- Claudins (CLDN), members of a large family of adherent junction proteins, regulate the integrity and function of tight junctions and influence tumorigenesis. It has been shown in recent studies that altered levels of the different claudins may be related to invasion and progression of...
Edited by: JV
Caspase-8 and P-P38 expression in clear cell renal cell carcinoma
Tuesday, 4 November 2008- Researchers from Athens, Greece, assessed and correlated the expression of caspase-8 and phosphorylated p38 mitogen-activated protein kinase (p-p38) with histopathological characteristics and clinical outcome in patients with clear cell renal cell carcinoma (ccRCC).
Arvanitis, Ferakis...
Edited by: JV
Effects of extracorporeal shockwave lithotripsy on renal vasculature and renal resistive index
Monday, 3 November 2008- It is known that extracorporeal shock wave lithotripsy (ESWL) can encourage also significant acute renal injuries and long-term complications of renal vasculature. Effects on renal vasculature can be evaluated by colour Doppler ultrasonography measuring renal resistive index(RI)....
Edited by: JV
Polymorphisms in genes may affect PCa risk
Friday, 31 October 2008 - Polymorphisms in genes which regulate steroid hormone metabolism may affect the risk of prostate cancer. Thymine to cytosine polymorphisms that occur in the 5’ promoter region of CYP 17 gene, exon 1/codone 10 of ER-a gene and 3’ untranslated region of INS gene have been associated with...
Edited by: JV
Radioisotope detection of sentinel lymph nodes high-risk PCa
Thursday, 30 October 2008- Although amenable to radical surgical excision, clinically localised high-risk prostate cancer (HR PC) is associated with a higher incidence of pelvic lymph node metastases. Hinev and colleagues (Varna/Pleven, Bulgaria) explored the efficacy of the radioisotope method to detect the...
Edited by: JV
