Survival advantage and pre-emptive kidney transplant
Friday, 25 December 2009- Pre-dialysis transplant recipients with a high level of kidney function do not appear to benefit from their transplant more than pre-dialysis recipients with a low level of kidney function, according to a recent study conducted by US researchers.
The findings, presented at the American Society of Nephrology's Renal Week conference recently held in San Diego, California, USA, suggest that pre-dialysis patients need not rush to have a pre-emptive transplant.
Patients who have undergone pre-emptive transplantation tend to live longer and have higher functioning transplants than post-dialysis transplant recipients. However, studies have not looked whether higher kidney function among pre-dialysis recipients improves patients' long-term health.
Using data from the United Network for Organ Sharing, researchers at Stanford University School of Medicine in Stanford, Calif., identified 25,748 pre-emptive transplant recipients and divided them into two groups: patients with higher kidney function and patients with lower kidney function at the time of transplant.
Patient and kidney transplant survival were similar in the two groups. The high-level group had a 34% decreased risk of acute rejection at six months post-transplant and a 35% reduced risk of requiring dialysis within the first week after transplantation.
"Based on these findings, we feel that patients and transplant experts anticipating a pre-emptive kidney transplant can wait for clinical indications to emerge without any significant loss of survival advantage associated with a pre-emptive transplant," said Dr. Basit Javaid, assistant professor of medicine at Stanford.
Source: American Society of Nephrology's Renal Week