Impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function of the kidney
Monday, 30 April 2012- In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D level on subsequent graft function has not been explored.
H. Kim and colleagues conducted a study to examine the effect of serum vitamin D level at the time of kidney transplantation (KT) on subsequent graft function. They published their findings in the online edition of BMC Nephrology.
In their study they analyzed 106 patients who underwent KT and for whom 25-hydroxy vitamin D (25- OHD) levels were measured during hospitalization prior to transplantation. The researchers also measured estimated glomerular filtration rates (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula at baseline and at six-month intervals up to 36 months after KT.
The results showed that 38.7% of the patients were diagnosed with 25-OHD deficiency defined as less than 10 ng/mL. Recipient gender (female vs. male, odds ratio [OR] 3.30, 95% CI 1.33-8.21, P = 0.010), serum albumin level (per 1 mg/dl increase, OR 0.35, 95% CI 0.13-0.98, P = 0.047), and predominant renal replacement therapy modality before KT (P < 0.001) were found to be independent pretransplant risk factors for 25-OHD deficiency by multivariate logistic regression analysis.
Subsequent repeated measures analysis of covariance revealed that 25-OHD level had the only significant main effect on eGFR during the 36-month followup period [F (1, 88) = 12.07, P = 0.001].
“Pretransplant 25-OHD deficiency was significantly associated with a lower post-transplant eGFR, suggesting that 25-OHD may play an important role in maintaining graft function after KT,” the researchers concluded.
Source: H. Kim, et al., “The impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function: An observational study,” BMC Nephrology; 2012, 13:22 doi:10.1186/1471-2369-13-22