Urinary incontinence in men after one-to-one pelvic-floor muscle training following RP
Monday, 1 August 2011- Urinary incontinence is common immediately after prostate surgery. Men are often advised to do pelvic-floor exercises, but evidence to support this is inconclusive.
C. Glazener and colleagues conducted a study to establish if formal one-to-one pelvic floor muscle training reduces incontinence. They published their findings in a recent edition of The Lancet.
The authors undertook two randomised trials in men in the UK who were incontinent 6 weeks after radical prostatectomy (trial 1) or transurethral resection of the prostate (TURP; trial 2) to compare four sessions with a therapist over 3 months with standard care and lifestyle advice only.
Randomisation was by remote computer allocation. The study’s primary endpoints, collected via postal questionnaires, were participants' reports of urinary incontinence and incremental cost per quality-adjusted life year (QALY) after 12 months. Group assignment was masked from outcome assessors, but this masking was not possible for participants or caregivers. The researchers used intention-to-treat analyses to compare the primary outcome at 12 months.
In the intervention group in trial 1, the rate of urinary incontinence at 12 months (148 [76%] of 196) was not significantly different from the control group (151 [77%] of 195; absolute risk difference [RD] −1•9%, 95% CI −10 to 6). In trial 2, the difference in the rate of urinary incontinence at 12 months (126 [65%] of 194) from the control group was not significant (125 [62%] of 203; RD 3•4%, 95% CI −6 to 13).
Adjusting for minimisation factors or doing treatment-received analyses did not change these results in either trial. No adverse effects were reported. In both trials, the intervention resulted in higher mean costs per patient (£180 and £209 respectively) but we did not identify evidence of an economically important difference in QALYs (0•002 [95% CI −0•027 to 0•023] and −0•00003 [−0•026 to 0•026]).
In settings where information about pelvic-floor exercise is widely available, one-to-one conservative physical therapy for men who are incontinent after prostate surgery is unlikely to be effective or cost effective, according to the authors. They added that the high rates of persisting incontinence after 12 months suggest a substantial unrecognised and unmet need for management in these men.
Source: Cathryn Glazener, et al., "Urinary incontinence in men after formal one-to-one pelvic-floor muscle training following radical prostatectomy or transurethral resection of the prostate (MAPS): two parallel randomised controlled trials," The Lancet, Volume 378, Issue 9788, Pages 328 – 337; doi:10.1016/S0140-6736(11)60751-4